Invoices, shipping notifications, automated newsletters, automated notifications, All very reasonable uses for a no-reply email addresses, and the typical use case.

Spam is a completely different story, and rarely uses no-reply emails.

If you want to blackhole any information you request from companies than scratch your head why you can't find your tracking information or flight status/itinerary that's completely up to you. Ignoring the valid, reasonable and typical use cases is just absurd