I'd recommend using a framework such as the Serverless Framework[1], Chalice[2], Dawson[3], or Zappa[4]. As any other (web) development project, using a framework will alleviate a big part of the pain involved with a new technology.

Anyways, I'd recommend starting from learning the tools without using a framework first. You can find two coding sessions I published on Youtube[5][6].

[1]: https://serverless.com/

[2]: https://github.com/awslabs/chalice

[3]: https://dawson.sh/

[4]: https://github.com/Miserlou/Zappa

[5]: https://www.youtube.com/watch?v=NhGEik26324

[6]: https://www.youtube.com/watch?v=NlZjTn9SaWg