UUID v4 "spec" leaves 122 bits for randomness and has 6 fixed bits for "version" information. I'm suggesting that following the spec on such stuff is a total waste and serves no point, and you're better off with a random 128-bit number.
Well, then it's not an UUID. It's just 128 random bits. If you just want to be the most random possible, you can go 256, 512, 1024, etc. That may be what you want, but you can't say UUID v4 is a "total waste" or "serves no point".
It's purpose is to never collide with another UUID v4, not to be the most unique value ever.
UUIDv4 is a 122 bit random number. Having another 6 random bits won't make them collide.
Also if there's UUIDs in your system colliding with a 128 bit random numbers then the rng is broken or your UUID generator would be great to crack encryption keys.