Seems to me it would be just straightforward to get a list of people taking trazodone for long periods and measure their rates of neurodegeneration versus the general population versus those taking ssris.
Depression is repeatedly linked to changes in BDNF and neurogenesis, so you would probably just see greater neurodegeneration compared to healthy controls anyway. Post-marketing surveillance is hard to draw any causal conclusions from...
Trazodone helps me for sleep, it's incredible. I'm out like a light and it's not addictive. If you have nighttime anxiety and stress-related sleep issues, it can be a godsend.