It depends on who I am having my one-on-one with. If it is my day-to-day manager we discuss tasks for the sprint and beat, scheduling, task priority, some overall project status topics, etc. If I'm having a one-on-one with my line manager we discuss how I'm feeling overall, big picture in terms of the project or studio, what my goals are, what it looks like I'll be doing (or what I want to do) after the current project, performance feedback, etc.