Zooming (ctrl +,ctrl -) in Firefox is terrible, and with a 4k screen zooming is a key feature. I quit using firefox because of that. Chrome's zoom actually works.
I just changed the devpixelsperpx preference in Firefox. No need to mess with zooming anymore. FF should read the screen density automatically, but as annoyances go, this is a minor one (just set and forget).
It actually used to do it automatically, but it got more complaints from people who were surprised that it did so than complements from people who were thankful that they could read things without squinting.