I have it running on my Windows machine, and I've definitely hit some big limitations. I don't remember offhand what they were, but there was some software that completely failed to run. I do remember that tmux is completely unable to figure out what the current working directory is, which means when I restore my tmux session after restarting, all of the panes are reset back to the home folder.

Additionally, the terminal that comes with it is pretty crappy, but my internet searches don't turn up any way to get a better terminal that works with it. I also can't figure out where the Linux Subsystem filesystem is stored on my drive.