No but there is enough regional difference, between East Coast, South, West Coast and Pacific North West. Even though most of the suburbs look alike thanks to mono-cultures and business franchises. The general regional vibe if you observe has some stark contrasts.

Again USA is 300 million people, from Rio Grande Valley to Seattle. Spain has 4 different official languages, but more languages are spoken in US than Spain.

edit: I am not even counting the contrast of Native American Reservations to Metropolis like NY, LA.