I came across this photo (potential casing for new MBP): http://cdn.macrumors.com/article-new/2016/05/macbook_pro_2016_case_top.jpg
Notice the missing top row of function keys. People have speculated that this top row may be replaced by an OLED touch screen.
Comparing the above photo to the Macbook keyboard, it would seem that the top row includes the escape key: http://cdn.macrumors.com/article-new/2014/11/retinamacbookkeyboard-800x484.jpg
If this is the case, any software developer that uses the escape key a lot may not be very happy.
I have Caps Lock mapped to Ctrl and I'm glad that MacOS provides this option out of the box, but Caps Lock as Esc is not an option for me. I hope there will be an out of the box way to map Escape to something sensible. I'd trade ~ for Esc anytime, as long as ~ and ` are accessible via the OLED strip.