I've been trying to get into that, but I'm just not finding it to have the depth of Binding of Isaac. Then again, what does, in twitch-rogues? Maybe I just need to make it past the first sewer level before I give up.
A lot of the meta around NT has to do with knowing what weapons work well across stages of the game and are complementary, then balancing ammo requirements with the need to dish out spike damage.
If you haven't made it past the sewer that you've probably seen < 15% of the game. I've particularly found melee weapons(wrench) particularly good at dealing with the sewers.
I haven't played it yet (waiting for the full release), but this video about the many, many uses for a small rock sold me on backing Catacomb Kids: https://www.youtube.com/watch?v=N59tLIvQeJE
