What? It's really simple. First figure out what version of SMB/CIFS you're using and if that's compatible. Then figure out if you have packet encryption enabled and if that's compatible. Then figure out if the compatibility issue you're still experiencing is due to the volume being served by a non-Windows appliance or server. If it's Windows dig through group policy settings applied and start toggling them on and off desperately until you're ready to explode. Then after days or weeks of packet captures and support calls find out it was a known issue and get a firmware patch from the MFP manufacturer.
I just went through all of that when upgrading our file server to 2012 R2. Would not recommend. SMTP is easier but has its own problems (such as file size limits).
I've had it go both ways. I've found it easier in the past if someone already compromised security by disabling signing. But that was a long time ago in another life. Things have probably changed a lot since.