Blaming religion for setting back science is lazy. It's a nuanced topic - for each instance of antiscientific pressure you can find instances of e.g. the Catholic Church supporting scientific advances.

I would say no. The book had been around for 1700 years without anyone picking up on its ideas. For a book full of ideas nobody seems to have cared about or understood, that's a long time.

Had it not been erased chances, Newton would probably still have invented calculus.