While it may seem esoteric to some, I believe significant effort should be put into the sequencing and analysis of dogs genetics. Their selective breeding is truly the greatest genetic experiment ever performed: from to Chihuahuas and Great Danes to Scent Hounds to Sight hounds to retrievers to herding dogs. We have crazy-detailed knowledge we have of them including their behavior, differences in morphology (e.g.,size), diseases (cancers, neurological disorders, musclo-skeletal disorders, metabolic diversity). Genetically, an amazing range of diversity exists, with subsets in a spectrum from extremely inbred breeds to totally outbred mutts scatter throughout the world. This diversity dwarfs that of humans, with nearly none of the informed consent and data privacy challenges that will-and should--go with a human study. There are legions of fanatical dog owners that are easy to find that would likely be enthusiastic in having their pup participate. While I sit here with mutt at my feet, my primary motivation is the correlation of genetic variations with diversity in behavior, stature, health, and disease. I know good work is already being done in this area, but a lot more can be done with relatively modest resources compared to what is required for human studies, and the results would provide an amazing benchmark by which to help interpret the human data as we collect it.