i'm a one-man consulting band. for the past 2 years i've lived in different cities for ~3m at a time and worked from home or coffee shops. i'm in vancouver for at least a year right now, and renting a desk at a friend's (startup) offices. it makes a world of difference to be able to mentally separate my home, where i now mostly relax, and work, where i now mostly work.

alternatively, i heard mysql required that all of their remote employees needed to have a separate room at home where they worked from... i think having a separate space (whether it's in your home or not) helps a lot.