If you are doing life support, military systems, or HA big finance, then you are quite likely to be running on dedicated equipment, with dedicated circuits, and quite often highly customized/configured non-stop hardware/operating systems.
You are unlikely to be running such systems on AWS or GCE.
Yep. Those were originally Itanium-only, so their success was somewhat… limited, compared to IBM's "we're backwards compatible to punch cards" mainframes.
Only recently did Intel start to port over the mission critical features like CPU hotswap to Xeons, so they can finally let the Itanic die, so we're hopefully going to see more x86 devices with mainframe-like capabilities.
You are unlikely to be running such systems on AWS or GCE.