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I agree. Depending on how TMS treatment is setup, it could stimulate a particular region of the brain, or a large section (frontal lobe). EEG biofeedback can also be focused on a small section of the brain (eg. prefrontal cortex). Its possible the situation in the article was a result of parts of the brain being "out of balance" and creating different emotions than what the person previously experienced.

Even if TMS 'activated' the emotional areas of the brain (right frontotemporal) correctly, the person still may not be ready to use that brain region effectively. This is where therapy would likely help.

Through research, its believed that Autistic Spectrum Disorders are the result of poor neuronal connectivity between certain regions of the brain. I'm not sure TMS would help with that.

Disclaimer: I'm not a physician and this isn't medical advice.



Former neuroscientist here. Emotions are not confined to the right frontotemporal area. There's multiple regions involved. It appears the TMS here was targeted on dorsolateral PFC, but keep in mind that there will be spreading effects, and presumably post-treatment effects, too, that can be quite widespread.


> Emotions are not confined to the right frontotemporal area. That is true. I should have been more specific.

Just out of interest, do you believe that neuronal connectivity between regions of the brain are involved in ASD?


That's one of the more likely theories yeah. While the defining ASD characteristic is impaired social processing, which seems like it would be specific, scans show it has relatively wide effects throughout the brain. There's a host of differences. Some are possibly connectivity-based. Localized processing seems hyperactive, and longer-distance processing is hypoactive.

But, there are other issues as well. In developing ASD brains, there have been shown to be areas of excess cortical thickening, areas of cortical thinning, underactivation, etc.

Connectivity certainly plays a role, but given that structure and function are so deeply interrelated, it doesn't make much sense to try and separate them.

We think there's a strong genetic component, but nobody's been able to figure it out yet. It appears to be more developmental/structural, but there could also be a neurotransmitter component, given that a large fraction of ASD people have elevated serotonin levels, and report intestinal issues (intestines have huge numbers of ST receptors).

In short, pretend you're debugging an intermittent parallel error in a network 50x greater than the total number of computers on earth, every computer had to coordinate its protocols on the fly, and your only tools are telnet and email. I respect what my former colleagues do, but reality was way too murky.




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