I spent 20 minutes trying to find this reference and could not find anything convincingly close enough. It is a sci-fi reference or something that happened in our world? The only thing I could find was FireFly related. My concern in this case would be chronic toxicity, which does as you say occur in some cases at lower than pharmaceutical dosage levels. I would only be campaigning for raising Lithium in towns <25% percentile to a level found in towns in the 75% percentile. This would be relatively simple to communicate to people, and you could point to a road down the street from which people's Grandparents grew up and demonstrate that you would simply be replicating amounts found in that town naturally. I think what is more disturbing is the concept that most people have no idea what is in their water, not that we could arbitrage minerals between different towns and try to come to some kind of optimal mineral content. In the study I reference, the spread between "highest" and "lowest" Lithium content is between ~2000x and ~1000x less than is currently used in the pharmaceutical. So if <10% of Lithium patients have any signs of toxicity (real number, around 10%) and 1% have life threatening toxicity, we could (perhaps not perfect math) assume that only 0.001% of people would experience a similar issue in dosages of 1000x less. My thought is that dosages at that level are akin to living in an area with high Lithium naturally, or eating lots of seafood, and that people would at least consider it, if you could reduce the rate of suicide by 50%. I could be wrong though, lots of opposition to this thesis, including here, including among people who no doubt know far more science than I do.
> I spent 20 minutes trying to find this reference and could not find anything convincingly close enough. It is a sci-fi reference or something that happened in our world? The only thing I could find was FireFly related.
It is a scifi/firefly reference. Spoilers ahead for the Serenity movie.
Miranda is a planet on a far far "edge" of the Verse (the "known universe" in Firefly) and considered fictional before the events of Serenity as the Alliance had basically struck it from records (and it was deep in "Reaver space" where people of the Verse don't go without a serious death wish). An Alliance research program was tried there: G-23 Paxilon Hydrochlorate ("Pax") had been found to reduce aggression, and on Miranda it was tried on a large scale, spread throughout the planet via the air processors system.
The compound pacified 99.9% of the population so much they basically stopped all drive. They stopped working, talking, feeding, moving and ultimately leaving.
The remaining 0.1% blew a gasket and went the exact opposite becoming ultra-violent self-mutilating merciless and fearless animalistic — but not stupid — monsters: the reavers, which have plagued the Verse since.
Disturbingly relevant. It would be too easy to think we could just change the water and solve Bipolar, but the concept that a small percentage of people would rise up against it violently is not hard to imagine either.