I've done a fair bit of integration with handsontable from clojurescript. It has been excellent so far. Clojurescript isn't really a pure language, it just makes some types of purity the default. If you need to get dirty and mutable then that's simple, still simpler than plain js in my opinion.
Clojurescript and Clojure have very good interop with their host language, integrating 3rd party libs is very simple. To be fair, you will have to write the glue code more often than when working in js since there is a smaller user base.
Is your handsontable/cljs work open source? Would love to see it.
I have given up on handsontable being usable in a modern js setup. I had to fall back to including it in a script tag and get it to work. Am quite interested to see if I can build it in cljs
Unfortunately it's not, but I find out if that is a possibility.
And now that you mention it you have jogged my memory about having to sidestep our build process in some unfortunate ways. We're certainly not passing it through Google Closure, we have to use the handsontable build scripts to remove unused features.
Getting it to co-exist with React was the real tricky part, but Rum was quite useful in providing the hooks to make handsontable act like a react component.
The way you got handsontable to work in your setup. That would be awesome - that would be a good learning of how to integrate complex, legacy js packages in cljs.
Clojurescript and Clojure have very good interop with their host language, integrating 3rd party libs is very simple. To be fair, you will have to write the glue code more often than when working in js since there is a smaller user base.