An additional complication is the role of the billions of glial cells that are present in the brain. Their function of supporting neurons is quite well characterised, but they can also more specifically modulate neuronal function, so their place in a comprehensive connectome model shouldn't be ignored.

Then there is the network of vasculature, the flow of cerebrospinal fluid, interactions with hormones, and just generally all the interfacing with other bodily systems. All this would have to measured and modelled somehow too, in addition to all the billions of neurons.

I agree with the author, there's no way all this is going to solved any time soon.