Even with multiple registers in Vim, I still can't get my mind to think that way. I just link everything with the system clipboard because it's easier to deal with. How do you comprehend all of that hidden information in memory? To me, it seems like a useful feature if you do or can use it, but for most users it's just extra complexity.
Even worse with vim is there are operations like delete which push to the register stack without you intending it, it makes it really difficult to keep track of where your stuff is without looking.
Other than mapping the unnamed register to the system clipboard, I usually use a few specific registers — "a, "b for cut/copy and paste, and "q, "w for macros. Would be interesting to see how other vim users do it.
