Hmga1 reduces repressive histone marks (H3K27me3), effectively unlocking genes typically silenced after embryonic development. This process seems to tap into an evolutionarily preserved "blueprint" encoded in the DNA. By reactivating these dormant pathways, differentiated cells like cardiomyocytes regain some of the plasticity and regenerative capacity characteristic of embryonic cells. If we combine this with the work coming out of Dr. Michael Levin's Lab at Tufts (https://www.youtube.com/watch?v=XheAMrS8Q1c)showing the existence of electrical blueprints that orchestrate life, we should see, as we do in this study that the regeneration observed was precisely tailored to the injury, avoiding pathological outcomes like cardiomegaly or uncoordinated growth. This preserved blueprint exists in all differentiated cells.