Combining this with the 1 in 600 statistic of the grandparent comment, it seems like ~2000-3000 people played Russian Roulette last year. To me, that's even more astounding than the number of deaths -- although the number of deaths is certainly more tragic.
I have spun a revolver with one round in the cylinder. First, you wont wait for it to settle, so it doesn't matter. Second, a cylinder is pretty heavy, so even if you did, it's not that big an effect. Third, there is significant friction between the cylinder and the pin it rotates on, which will prevent it from settling in that manner. The 1:600 number isn't true.
That's assuming that everyone who dies from playing it only played it once. It could be that only 4 people played it at all, and they all played it ~600 times.