My 2C.. Our system doesn't provide the testing and data to make accurate, choices to build upon. We are at the mercy of over worked Drs, who look at basic tests, and often just have a minute to review at most. Our health is bound to the sheer luck of drawing a Dr who reads between the lines and can spot/sympathize/analyze our various issue(s).
My hypothesis is that there is too much variance in day to day life, activity, stress, food and liquid intake. In order to really test something I'd like to limit variables by using health apps for BP and HR, limiting diet by using something like Soylent for a month. That would establish the baseline test, then implement the change/drug/supplement, and test daily or weekly.
FWIW Yohimbe made me feel like shit. I would caution anyone looking at quick fixes without reading and setting up groundwork to accurately test yourself, even if its only anecdotal.
Why do I say we need to personally track things? There's a lot to learn.
Is your system starved for, or already flooded with the element you're about to consume? Is your system lacking a precursor? Is your system failing downstream to break something else down which is causing a cascading build up? Everybody up-regulates and down-regulates stimulants, catacholamines, etc at different rates. Are you able to break it down from it's required co-factors upstream or downstream? As for Yohimbe, our adrenergic receptors are part of the puzzle there.
Many people have metabolic enzymatic variances, deficiencies, to full blown impairment and we all have changing levels of receptors. Some elements cross the blood brain barrier, some don't. Some people can benefit from a supplement, or an enzyme but to others it's actually detrimental since it may block another pathway. Even commonly known Dopamine and Serotonin require various ingredients that may or may not be present in our systems such as dopamine beta hydroxylase, LDopa, BH4, etc. Various receptor density in any area can impact both the uptake and down regulation, while cascading their impact neighboring systems.
We as humans, are all very different on what works, and what doesn't. It sucks, and it's amazing.
All very good points. I do feel that part of the problem is attitudinal - I am from Europe and have been to psychiatrists in 2 countries with public health systems as well as privately here (where I paid out of pocket without even asking for a discount).
Of course psychiatrists have a difficult job - there isn't a simple blood test for many mental conditions, for example, so starting out by compiling checklists is almost unavoidable. But none of the psychiatrists whose care I've ever been under (8 or 9 I think) has ever done so much as a blood draw or discussed even the possibility of doing a brain scan, or well, anything.
At best I've gotten confirmation for the research I did on the internet or in the library, and while I'm sure it's very annoying to have patients with no medical degree coming in and asking half-baked questions about this or that study, I don't feel very sympathetic considering that it's really the psychiatrist's job to apprise the patient of those options, or at least to take the patients' reports and suggestions seriously and work wit the information available.
While I'm (obviously) pissed off about all this, at the same time I consider myself very lucky - I live in the age of the internet and despite having a lot of mental problems I'm also smart and discriminating so at least I'm able to exert some influence over my own treatment. Most people with mental illness enjoy no such advantages. My best friend suffered a psychotic break about a year ago and was institutionalized for most of a month, right here in the Bay Area. Conditions were better than a jail, but not much. I was especially struck by the dire low quality of the food; how can you expect people to get better when their nutrition is such an obviously low priority?
I'm going to shut up now - as you can see I have a vested interest in this topic and the inequities anger me so much that it doesn't make for good conversation. Apologies to my fellow HNers who may have found this difficult to read.
That's it. And I run Drupal on my personal site as well as you noted. I have a handful of other Drupal sites and a couple WordPress sites I help with, too. I'll probably upgrade my personal site first and my internal test sites running on local server instances to play with.
While this comment is funny, it's also arrogant and incorrect. It's not fair to indict folks trying to change lives based on what's needed to drive pageviews, ie attention grabbing headlines.
30 seconds of research provides a pretty obvious connection, regardless of your "no fucking clue what they're doing" accusation...
It's apparent that Nilotinib plays a role with Serotonin, which is of course implicated in Parkisons and many other neurological disorders, but I guess we are hung up on cute headlines and not the real story.
http://phys.org/news/2010-06-serotonin-decades-old-mystery-p...
Also, drug repurposing is often a highly data-driven field. So it may not involve predictions where there's a high degree of certainty, but data-driven methods can shift a 1 in a million (or more) chance of success into a 1 in 3 or 1 in 5. Such wins are absolutely huge.
Pure speculation but interesting... The timing may have something to do with Wix, a Google Domains partner, who is having difficulty with their customer sites being indexed. The support thread shows a lot of talk around "we are following Google's Ajax guidelines so this must be a problem with Google". John Mueller is active in that thread so it's not out of the realm of possibility someone was asked to make a stronger public statement.
http://searchengineland.com/google-working-on-fixing-problem...
I'm betting that they finally solved the scalability problems with headless WebKit. Google's been able to index JS since about 2010, but when I left in 2014, you couldn't rely on this for anything but the extreme head of the site distribution because they could only run WebKit/V8 on a limited subset of sites with the resources they had available. Either they got a whole bunch more machines devoted to indexing or they figured out how to speed it up significantly.
I'd say both are pretty likely.. another round of lower-power servers with potentially more cores... more infrastructure... Combined with improvements in headless rendering pipelines. I haven't looked into it in well over a year now, but last I checked dynamic updates took about 2-3 days to get discovered vs. server-delivered being hours for a relatively popular site.
I'm guessing they've likely cut this time in half through a combination of additional resources, and performance improvements. Wondering if they'd be willing to push this out as something better than PhantomJS... probably not as it's a pretty big competative advantage.
I know MS has been doing JS rendering for a few years, they show up in analytics traffic (big time if you change your routing scheme on a site with lots of routes, will throw off your numbers).
The article is published on Cult of Mac. The blogs audience is most likely only interested in Apple related news and events. For its target audience it is perfectly acceptable to present Apples role, even being a minor player.
Google is already working to attribute authors to content, think of it as PersonRank. With verified real people (they are getting many signals for this such as android, chrome, checkout, places, voice, plus, etc) they may be able to combat spam like this by ranking news/stories based on the history of the author.
This was the same thing that caught my eye as well. I said congrats on the launch, and Dan was right there with a quick friendly comment. This alone convinced me to try it as I was on the fence.
The signup/interview through checkout process took about 30 seconds. Curiously awaiting the results. Thanks again Dan.
Agree, though reputation rank may mitigate some of this behavior when implemented. The urls +1 profile distribution may end up looking like a typical back link profile and something most SEOs should try and balance.
