I am a tad perturbed that a quick skim didn't present to my eyes any statements along the lines of "But we never tried it, at all, so take it with a grain of salt."
Either that or I somehow completely missed the table showing the effect of the schedule on subjects vs. controls, or any other sort of experimental confirmation whatsoever.
To be clear I don't object to the analysis or its methods, I object that it's not being clearly confessed to be an analysis in bold letters.
This just a numerical simulation on two (simple) models of the human sleep cycle system that tries to find a more efficient way of shifting the cycle of those methods.
I've only spend 40 minutes reading the paper so far and only have a superficial understanding of it, but to me it looks like they are using a somewhat oscillator like model and looking to introduce a phase shift in the response by driving it with different input functions.
There is no experimental verification whatsoever. This is why this was in the computational biology section of plosone.
I've been meaning to ask if you've read up on chronotherapeutics; when I read the book (that I cited above, in top-level) a few months ago it seemed to explain why the melatonin procedure that MetaMed gave you worked - a full biological basis. I didn't follow that up, though, since I was trying to fix my own DSPS.
Either that or I somehow completely missed the table showing the effect of the schedule on subjects vs. controls, or any other sort of experimental confirmation whatsoever.
To be clear I don't object to the analysis or its methods, I object that it's not being clearly confessed to be an analysis in bold letters.