There are many films and books about the Holocaust, I don't think games should be treated any differently.
I do agree with the general sentiment that making games about the holocaust is probably not a good idea, but if someone did it and did it well, I wouldn't hesitate to play it. Not all games have to be trivial.
Agreed. Just throwing in some concentration camps and gas chambers in a tower defense game would be unneeded and tasteless. However an realistic game where you had to escape from a concentration camp or aid escapees that employed a lot of stealth(Thief) elements with realistic/gritty world (DayZ comes to mind but without Zombies) and the sequences could be based on some of the true life stories.
I do agree with the general sentiment that making games about the holocaust is probably not a good idea, but if someone did it and did it well, I wouldn't hesitate to play it. Not all games have to be trivial.