I had a shot at Aida-Web, not my cup of tea. Does the job though. Amber is another beast, and is a very good option for single page web apps. Can do proxying of JavaScript objects, so you can harness whatever you like in your code and use the JS API the Smalltalk way. Which is kind of cool. With the Helios IDE, it is a killer. Needs a while to master but worth the time.