In screen, splits and windows behave more like vim buffers and splits. That works nice for an editor because I might want to look at the same file at two different locations. I find it weird to apply that concept to shells.

Tmux panes and windows behave more like separate shells. It's similar to what we get with individual shell gui windows that are neatly stacked and makes it easy to follow.

I don't know if there is an equivalent in screen, but I like and heavily use the zoom feature which can temporarily minimize other splits and focus on single shell.