Yes. I work on regex engines. Here's the code with all the crazy checks that return errors that can never happen:

    fn find_fwd_imp<A: Automaton + ?Sized>(
        dfa: &A,
        input: &Input<'_, '_>,
        pre: Option<&'_ dyn Prefilter>,
        earliest: bool,
    ) -> Result<Option<HalfMatch>, MatchError> {
        let mut mat = None;
        let mut sid = init_fwd(dfa, input)?;
        let mut at = input.start();
        while at < input.end() {
            let byte = match input.haystack().get(at) {
                None => return Err(MatchError::GaveUp { offset: at }),
                Some(&byte) => byte,
            };
            sid = dfa.try_next_state(sid, byte)?;
            if dfa.is_special_state(sid) {
                if dfa.is_match_state(sid) {
                    let pattern = dfa.match_pattern(sid, 0);
                    mat = Some(HalfMatch::new(pattern, at));
                } else if dfa.is_dead_state(sid) {
                    return Ok(mat);
                }
            }
            at = match at.checked_add(1) {
                None => return Err(MatchError::GaveUp { offset: at }),
                Some(at) => at,
            };
        }
        eoi_fwd(dfa, input, &mut sid, &mut mat)?;
        Ok(mat)
    }

And here's a search (I ran it a few times):

    $ regex-cli count matches dfa dense @$medium '\w{42}'
                parse time:  45.331µs
            translate time:  28.767µs
          compile nfa time:  9.577558ms
                nfa memory:  698148
    compile dense dfa time:  516.497476ms
          dense dfa memory:  6562848
     dense alphabet length:  113
              dense stride:  128
               search time:  531.808124ms
                    counts:  [2]

Here's code that's safe that will panic when there's a bug:

    fn find_fwd_imp<A: Automaton + ?Sized>(
        dfa: &A,
        input: &Input<'_, '_>,
        pre: Option<&'_ dyn Prefilter>,
        earliest: bool,
    ) -> Result<Option<HalfMatch>, MatchError> {
        let mut mat = None;
        let mut sid = init_fwd(dfa, input)?;
        let mut at = input.start();
        while at < input.end() {
            sid = dfa.next_state(sid, input.haystack()[at]);
            if dfa.is_special_state(sid) {
                if dfa.is_match_state(sid) {
                    let pattern = dfa.match_pattern(sid, 0);
                    mat = Some(HalfMatch::new(pattern, at));
                } else if dfa.is_dead_state(sid) {
                    return Ok(mat);
                }
            }
            at += 1;
        }
        eoi_fwd(dfa, input, &mut sid, &mut mat)?;
        Ok(mat)
    }

And here's a search with it:

    $ regex-cli count matches dfa dense @$medium '\w{42}'
                parse time:  33.701µs
            translate time:  24.264µs
          compile nfa time:  9.55935ms
                nfa memory:  698148
    compile dense dfa time:  550.959698ms
          dense dfa memory:  6562848
     dense alphabet length:  113
              dense stride:  128
               search time:  468.932568ms
                    counts:  [2]

So that's 10% right there. We can keep going though. Let's get rid of the bounds checks. We have to use unsafe though. The stakes have risen. Now if there's a bug, we probably won't get a panic. Instead we get UB. Which might lead to all sorts of bad stuff.

    fn find_fwd_imp<A: Automaton + ?Sized>(
        dfa: &A,
        input: &Input<'_, '_>,
        pre: Option<&'_ dyn Prefilter>,
        earliest: bool,
    ) -> Result<Option<HalfMatch>, MatchError> {
        let mut mat = None;
        let mut sid = init_fwd(dfa, input)?;
        let mut at = input.start();
        while at < input.end() {
            sid = unsafe {
                let byte = *input.haystack().get_unchecked(at);
                dfa.next_state_unchecked(sid, byte)
            };
            if dfa.is_special_state(sid) {
                if dfa.is_match_state(sid) {
                    let pattern = dfa.match_pattern(sid, 0);
                    mat = Some(HalfMatch::new(pattern, at));
                } else if dfa.is_dead_state(sid) {
                    return Ok(mat);
                }
            }
            at += 1;
        }
        eoi_fwd(dfa, input, &mut sid, &mut mat)?;
        Ok(mat)
    }

And now the same search:

    $ regex-cli count matches dfa dense @$medium '\w{42}'
                parse time:  22.511µs
            translate time:  26.843µs
          compile nfa time:  8.709352ms
                nfa memory:  698148
    compile dense dfa time:  565.365005ms
          dense dfa memory:  6562848
     dense alphabet length:  113
              dense stride:  128
               search time:  456.402963ms
                    counts:  [2]

For a smaller gain.