Dr. Sinclair's book Lifespan (https://www.amazon.com/Lifespan-Why-Age_and-Dont-Have/dp/150...) talks about extending the health span of people. I've been personally taking 1g/day of NMN for almost 3 years now, and I feel like aging has paused or is going backwards slowly.
considering he leads a research group at Harvard that publishes in high profile journals, you could actually look at the peer reviewed research, instead of relying on your "hunch"
It's old news but did you know, He did fuck GSK for 750 million? Basically no one could ever replicate his study. GSK should have done thier homework so boohoo for them but still all is not what it seems.
I’m 38. I’ve beaten the hell out of my poor aging frame. And then fixed a lot of those injuries to my poor aging frame by not playing rugby any more.
All of which to say: there is absolutely no way you are possibly controlling for all variables here. Things off the top of my head that could help with exercise recovery, all of which are more plausible than some poorly tested supplement:
- Changes in exercise type
- Changes in exercise duration
- Changes in exercise intensity
- Changes in exercise form
- Weight loss
- Sleeping more for better recovery
I find the first 3 episodes to be absolutely stellar and was engrossed the whole hour. Pretty good takeaways.
The more recent ones are a little contentious and, as he himself admits, a little pseudosciency. He even says that these supplements are marginally helpful, and perhaps the most beneficial things is literally to just walk after a meal. Partially as a result, and partially because the recent episodes's concepts weren't explained well, I found myself distracted.
Random-- he makes a comment how the FDA often prematurely bans things e.g. peptides, which greatly hampers researchers' access to these materials.
I'm going to save you some money. What really works well and better than taking NMN orally(), eat a natural clean whole food diet (no pufa's or processed food), no alcohol or smoking and walk or do some sort of light exercise for about 30-60 minutes a day.
I am willing to bet it will do more for you than taking NMN.
Peter Attia has discussed this with folks who know a lot more than Sinclair and they have concluded there is no evidence it works. The number one thing you can do to extend lifespan is exercise.
I am doing some experiments with NR (no Sinclair in the business chain AFAIK) and pterostilbene and my ability to exercise has improved noticeably. I am 43 and I used to be fairly sore after a strenuous 60 minute exercise - especially my sinews were bad. This wasn't getting any better with more exercise, actually it was slowly getting worse with age, to the degree that I wasn't able to exercise in two consecutive days and sometimes I had to wait until the third day to go to the gym again. (To be clear, I am neither fat nor riddled with any serious disease.)
Nowadays the small pains and aches go away in a few hours, like when I was some 15 years younger. But if I stop the supplementation, the situation reverts to the old bad standard within a month or so.
I also noticed some effect on my visual acuity.
I know this is N == 1, hard to measure precisely and subject to a possible placebo effect.
I had a similar response doing a mostly vegan calorie restricted low protein diet. I was blown away because I had always been told protein = recovery, calories = recovery, but I have been able to rock climb pretty hard 6 days a week for the past 4 months now. Keto, general healthy eating, tons of supplements and all the other things I have tried have resulted in maybe 3-4 hard sessions a week and achy joints.
Note I am not disputing NAD supplementation, only the limits of what it can do and who can benefit from it.
The key to NAD supplementation is the people who need it are older or ill.
There are a lot of other processes in such bodies that become deficient too.
None of the supplement methods for NAD, Niacin, NR, NMN will boost levels beyond what your body will use.
This is what the NAD cycle looks like, you can see NA (niacin) vs NR vs NMN are each closer to production but the end result is the same of what ends up in the blood vs organs like liver.
There are wild arguments, even with scientific rigor, about NR vs NMN ability to get into cells. It is more likely that genetics matters and it varies from person to person and what else is in their diet.
Why disregard someone simply because they own a piece of a company that also supports the goal? I think any rational person would do the same - you believe in something so you start, invest in, or advise a company.
I think the comment also said that this person’s views aren’t taken seriously in the aging research community. So the combination of their ideas and a desire to profit from them raises flags.
I don't think Harvard would let Sinclair have a lab with some 35 people and publish articles under their name if he was a total fraud/quack.
My impression of Sinclair is that he likes public attention too much and often reports on work in progress with too much certainty, but results like this [1] seem to be fairly impressive.
