For some reason, in Chrome 13 on OS X, some of the UI animations cause the browser view to go black for a second and redraw. Not sure if this is just a Chrome bug but it's really obnoxious and means I won't use it until it's smoother.
It can be seen as flicker in Windows and there are some reports of black flashes in OS X. Switching the 3D acceleration off seems to fix them, but unfortunately it can be done only with a command line switch. We may forfeit the CSS transition animations in Chrome in later releases if we can't find a fix for these issues.