Randomly chiming in here, but now that I've used Hiccup (in Clojure) for a few years, nothing else seems evenly remotely pleasant to use. Especially when it's hooked up to a good IDE for super-easy key bindings (emacs + paredit for me).
Also chiming in. I like Jinja and handlebars and mustache and JSX makes me want to puke. I love Ractive but hate React. Recently back on django and have done a bit of django-ractive messing about so yes it is crazy. It'll never work. You get them mixed up in your head and it makes your brain hurt. But maybe this is a better. I give it a go.